devlaming.eu

Welcome to the homepage of Ronald de Vlaming, Assistant Professor at the Depart of Econometrics and Data Science, School of Business and Economics, Vrij Universiteit Amsterdam.

Using a wide range of simulations, researchers from the Vrije Universiteit Amsterdam, Erasmus University Rotterdam, and University of Bologna have compared two techniques to overcome attenuation bias in regressions using polygenic indices. These simulations have been carried out using the GNAMES tool, which is available on GitHub. The manuscript has been published in Nature Communications.

Researchers from the Vrije Universiteit Amsterdam, Erasmus University Rotterdam, and University of Cambridge have developed a method for Mediation Analysis using GREML (MA-GREML). This method is able to quantify the degree to which the genetic variance of a given outcome is mediated by an intermediate trait. MA-GREML is incorporated in the MGREML tool, which is available on GitHub. The method and some applications have been published in PLOS Genetics.

Researchers from the Vrije Universiteit Amsterdam, Erasmus University Rotterdam, University of Cambridge, McGill University, and University of Wisconsin-Madison have developed a new tool for joint, efficient estimation of large genetic correlation matrices. This command-line tool, called MGREML, is available on GitHub. The manuscript in which MGREML is described and applied to 74 brain measures and several behavioural traits has been published in Communications Biology.

Researchers from the Vrije Universiteit Amsterdam and the University of Cambridge have developed JADOC: a new method for joint approximate diagonalization of multiple positive (semi)-definite matrices. This method is implemented as a tool for Python 3.x and is available on GitHub. The article in which JADOC is described is now available as preprint on arXiv

The MetaGAP calculator described by De Vlaming et al. (2016) can be accessed here or using the menu. Edit [4/30/18]: the manuscript on the MetaGAP calculator has now also been published in PLOS Genetics.